Our laboratory uses high-throughput data to analyze cancer, lung diseases, and pathogenic bacterial infections. Research topics include cancer information analysis, bioinformatics analysis tools, database development, and microbial genomics. By cooperating with hospital physicians and other research scholars, our laboratory aims to: (1) assist physicians and researchers to identify mutations related to pathogenic mechanisms and drug resistance, by developing or using existing bioinformatics resources tools; and (2) treat or control nosocomial infection, by applying an understanding of these underlying mechanisms. It is envisaged that the process of analysis will lead to advances in bioinformatics analysis tools and database development.
Projects in progress in the laboratory include:
1. The development of a method for constructing a predictive cancer prognosis model that uses the data of transcripts and genomes in The Cancer Genome Atlas (TCGA) database of the United States.
2. The development of tools for the analysis of chromatin immunoprecipitation sequencing data for non-modal species.
The laboratory’s external cooperation plan includes:
1. Cross-Body Data Integration – a joint project with The Chang Gung Molecular Medicine Research Center, to develop analysis tools that integrate cross-genome, transcript, and protein body data.
2. The Relationship Between Pathogenic Bacteria and The Host – a joint project with The Nephrology Department of Chang Gung Memorial Hospital, to explore host transcript changes after Leptospira infection.
3. Competitive Relationship of Endogenous RNA – a joint project with researchers at Baylor College of Medicine, to explore endogenous RNA competition in cells using data from the open database.
4. Multi-Drug-Resistant Bacterial Genomes – a joint project with The Microbiology and Immunology Department at Taipei Medical University, to explore the genetic variation of clinical isolates of multi-drug resistant bacteria through whole-genome sequencing.